Sometimes a mouse pointer disappears only when it moves over certain applications. If Your Pointer Only Disappears in Certain Apps It can also be that your GPU driver needs to be updated, so that it plays nicely with a newer mouse driver.

Alternatively, perhaps you should roll back a new mouse driver which may be causing problems. While Windows usually does a good job of keeping things up to date, you may want to manually check that your mouse drivers are up to date. If your mouse has this feature, make sure it’s set to the correct profile for the computer you want to use it on. So you can switch between different devices at the touch of a button. Some Bluetooth mice, such as the MX Master series, support multiple device profiles.